Pandit Raghunath Seth was born in Gwalior. As a boy, he was exposed to music through his family elders and developed an ear for it at a very young age. He went on to receive valuable guidance from the eminent musicologist Dr. S. N. Ratanjankar in Lucknow. On coming to Bombay, at the tender age of 19, he met Pandit. Pannalal Ghosh who enhanced his knowledge of the art of flute playing.
Pandit Seth has made major contributions towards the enhancement of flute design. He devised a bamboo key, which enabled him to play all the ragas with equal ease. With the use of the key, flautists can glide from the lowest to highest note and vice-versa. His innovation has received much recognition from the press and musicologists.
As a light music exponent, Pt. Seth started playing in film music since 1951. He served All India Radio, Lucknow as a music composer and music producer from 1954 - 1969. After this, he joined Films Division, Bombay as Director of Music. Besides providing excellent music in films, Raghunath Seth has a number of non-film light music albums to his credit and has recorded with artists Lata Mangeshkar, Asha Bhonsle, Talat Mehmood, Manna Dey, Hemant Kumar amongst others.